Pulmonary Administration of Gentamicin During Liquid Ventilation in a Newborn Lamb Lung Injury Model
نویسندگان
چکیده
منابع مشابه
Pulmonary administration of gentamicin during liquid ventilation in a newborn lamb lung injury model.
OBJECTIVES Newborns with pulmonary infection frequently present with acute lung injury leading to ventilation/perfusion abnormalities in which intravenous delivery of antibiotics to the lung can be suboptimal. Tidal liquid ventilation (TLV) has been shown to be an effective means for delivering drugs directly to the pulmonary system. The objective of this study was to compare, with lung injury,...
متن کاملChanges in pulmonary blood flow during gaseous and partial liquid ventilation in experimental acute lung injury.
BACKGROUND It has been proposed that partial liquid ventilation (PLV) causes a compression of the pulmonary vasculature by the dense perfluorocarbons and a subsequent redistribution of pulmonary blood flow from dorsal to better-ventilated middle and ventral lung regions, thereby improving arterial oxygenation in situations of acute lung injury. METHODS After induction of acute lung injury by ...
متن کاملHigh frequency oscillatory ventilation versus conventional ventilation in a newborn piglet model with acute lung injury.
BACKGROUND High frequency oscillatory ventilation (HFOV) is considered a protective strategy for human lungs. This study was designed to define microscopic structural features of lung injury following HFOV with a high lung volume strategy in newborn piglets with acute lung injury. METHODS After acute lung injury with saline lavage, newborn piglets were randomly assigned to 5 study groups (6 i...
متن کاملProne Positioning Improves Oxygenation Without Adverse Hemodynamic Effects during Partial Liquid Ventilation in a Canine Model of Acute Lung Injury
BACKGROUND Partial liquid ventilation (PLV) and prone positioning can improve the arterial oxygenation (PaO2) in acute lung injury (ALI). We evaluated the effect of prolonged prone positioning during partial liquid ventilation (PLV) in a canine model of acute lung injury. METHODS Six mongrel dogs (weighing 17.4 +/- 0.7 kg each) were anesthetized, intubated and mechanically ventilated. After 1...
متن کاملPulmonary vagal innervation is required to establish adequate alveolar ventilation in the newborn lamb.
To investigate the effects of bilateral intrathoracic vagotomy on the establishment of continuous breathing and effective gas exchange at birth, we studied 8 chronically instrumented, unanesthetized, sham-operated and 14 vagotomized newborn lambs after a spontaneous, unassisted vaginal delivery. Fetal lambs were instrumented in utero to record sleep states, diaphragmatic electromyogram, blood p...
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ژورنال
عنوان ژورنال: PEDIATRICS
سال: 1997
ISSN: 0031-4005,1098-4275
DOI: 10.1542/peds.100.5.e5